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Nutraceutical Ingredients Dietary supplement ingredient amino acid L-Citrulline AJI92

WUHAN SOLEADO TECHNOLOGY CO.,LTD.
WUHAN SOLEADO TECHNOLOGY CO.,LTD.
City: Wuhan
Province/State: Hubei
Country/Region: China
Tel: 86-27-83341481

Nutraceutical Ingredients Dietary supplement ingredient amino acid L-Citrulline AJI92

Place of Origin : China
Brand Name : Soleado
Model Number : 372-75-8
MOQ : 25kg
Price : Latest USD/kg
Packaging Details : 25kg/drum
Delivery Time : 7days after confirmation
Payment Terms : L/C, D/A, D/P, T/T, Western Union, MoneyGram, ESCROW
Supply Ability : 25tons/month
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Nutraceutical Ingredients Dietary supplement ingredient amino acid L-Citrulline AJI92
English name: L-CitrullineCAS No :372-75-8Molecular formula: C6H13N3O3
Molecular Weight: 175.19Physical Properties: L-citrulline is white crystal or crystalline powder, sour taste, slightly soluble in water, soluble in alcohol and ether.
The organic compound citrulline is an α-amino acid. Its name is derived from citrullus, the Latin word for watermelon, from which it was first isolated in 1930.[2] It has the idealized formula H2NC(O)NH(CH2)3CH(NH2)CO2H. It is a key intermediate in the urea cycle, the pathway by which mammals excrete ammonia.

Biosynthesis
Citrulline is made from ornithine and carbamoyl phosphate in one of the central reactions in the urea cycle. It is also produced from arginine as a by-product of the reaction catalyzed by NOSfamily (NOS; EC 1.14.13.39). Arginine is first oxidized into N-hydroxyl-arginine, which is then further oxidized to citrulline concomitant with release of nitric oxide.
Function
Although citrulline is not coded for by DNA directly, several proteins are known to contain citrulline as a result of a posttranslational modification. These citrulline residues are generated by a family of enzymes called peptidylarginine deiminases (PADs), which convert arginine into citrulline in a process called citrullination or deimination. Proteins that normally contain citrulline residues include myelin basic protein (MBP), filaggrin, and several histone proteins, whereas other proteins, such as fibrin and vimentin are susceptible to citrullination during cell death and tissue inflammation.
Patients with rheumatoid arthritis often have detectable antibodies against proteins containing citrulline. Although the origin of this immune response is not known, detection of antibodies reactive with citrulline (anti-citrullinated protein antibodies) containing proteins or peptides is now becoming an important help in the diagnosis of rheumatoid arthritis.
In recent studies, citrulline has been found to relax blood vessels. Circulating citrulline concentration is, in humans, a biomarker of intestinal functionality
Sources
Citrulline in the form of citrulline malate is sold as a performance-enhancing athletic dietary supplement, which was shown to reduce muscle fatigue in a preliminary clinical trial.
The rind of watermelon (Citrullus lanatus) is a good natural source of citrulline.

Applications:
Pharmaceutical raw material and dietary supplement ingredient.
Purpose: to improve immune system function; maintain the function of joint movement; maintain the normal blood sugar levels; rich in antioxidants, absorb harmful free radicals; help to maintain normal cholesterol levels.Improve healthy sex function: citrulline and ammonia react in the human body, generate arginine and nitric oxide. Nitric oxide activates guanylyl cyclase enzyme, resulting in smooth muscle relaxation. It also can make the blood vessels get loose, used to enhance male sexual function, and the treatment of sexual dysfunction.To maintain human health in lung function.Improve mental clarity. Help brain cells back message with a storage function. This is a key to memory and learning; reduce stress and overcome frustration.

Specifications:

Item

Specification( AJI92)

Results

Description

White crystals or crystalline powder

Conforms

Stata of solution

(transmittance)

Clear and colorless

Not less than 98.0%


99.3%

Specific rotation [α]D20

+24.5°to +26.8°

+26.10°


Chloride (Cl)

Not more than 0.020%

0.011%

Ammonium (NH4)

Not more than 0.02%

0.012%


Sulfate(SO4)

Not more than 0.020%

0.01%


Iron(Fe)

Not more than 10ppm

6ppm


Arsenic (As2O3)

Not more than 1ppm


Not more than 1ppm


Heavy metals(Pb)

Not more than 10ppm

5ppm


Other amino acids

Chromatographically

Not detectable

Conforms


Loss on drying


Not more than 0.30%

0.20%

Residue on ignition

(sulfated)


Not more than 0.10%

0.06%

Assay

98.0% to 101.0%

99.91%


PH

5.0 to 7.0

6.2

Conclusion: compliant with the specification of AJI92


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Nutraceutical Ingredients Dietary supplement ingredient amino acid L-Citrulline AJI92 Images

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